Pinealon is a synthetic tripeptide bioregulator originally developed to investigate the restoration of pineal gland function and the preservation of neuronal integrity.

Peptide Classification and Description

Pinealon (Glu-Asp-Arg) is a synthetic tripeptide that belongs to a class of compounds known as "bioregulators". It is specifically engineered to mimic endogenous signaling molecules in the brain, with a high degree of tissue-specificity for the pineal gland and central nervous system (CNS). Due to its short amino acid sequence, it is capable of crossing the blood-brain barrier and potentially interacting directly with the cell genome to modulate gene expression.

Targets, Effects, and Explored Roles

Category	Pinealon Research Details
Primary Targets	Pineal gland tissue, hippocampal neurons, and mitochondrial membranes.
Potential Effects	Normalization of melatonin synthesis, reduction of reactive oxygen species (ROS), and enhanced neuronal survival.
Explored Roles	Studies focus on circadian rhythm regulation, age-related cognitive decline, and neuroprotection during hypoxic events.

Core Mechanism and Function

Peptide	Mechanism of Action	Key Biological Function
Pinealon	Functions as a gene expression regulator and antioxidant-like peptide.	Supports cellular vitality by balancing pro- and anti-apoptotic proteins and optimizing brain energy metabolism.

Clinical Potential

While designated strictly for research use, the neurobiological pathways influenced by Pinealon are a major focus in gerontology and neurology research:

Cognitive Enhancement: Investigating significant improvements in memory retention, attention span, and processing speed in aging models.
Sleep-Wake Optimization: Researching the synchronization of circadian rhythms and the restoration of natural sleep architecture.
Neurodegenerative Research: Exploring its potential to prevent the accumulation of misfolded proteins and reduce markers of neurodegeneration.
TBI and Stroke Recovery: Studying its role in reducing caspase-3 enzyme levels to mitigate apoptotic cell death following oxygen deprivation.

Product Specifications

Specification	Details
Form	Lyophilized powder in 3 mL glass vial
Appearance	Solid, white to off-white powder
Chemical Formula	$C_{15}H_{26}N_{6}O_{8}$
PubChem CID	10273502
CAS Number	175175-23-2
Molecular Weight	~418.41 g/mol
Storage	Store at ≤ -20°C for long-term stability

Strictly RUO: This product is for Research Use Only. Bodily introduction into humans or animals is strictly forbidden.

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