IGF-1 LR3 is a synthetic analogue of human Insulin-like Growth Factor-1 (IGF-1), engineered to provide significantly enhanced potency and metabolic stability in experimental models.

Peptide Classification and Description

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a recombinant 83-amino acid peptide. It differs from endogenous IGF-1 through two key modifications: the addition of 13 amino acids at the N-terminus and the substitution of arginine for glutamic acid at the third position. These alterations theorized to reduce its affinity for IGF-binding proteins (IGFBPs), extending its biological half-life from approximately 20 minutes to nearly 20–30 hours.

Targets, Effects, and Explored Roles

Category	IGF-1 LR3 Research Details
Primary Targets	High affinity for the IGF-1 receptor (IGF1R) on muscle, bone, and connective tissue cells.
Potential Effects	Induction of muscle hypertrophy, enhanced nitrogen retention, and improved nutrient partitioning.
Explored Roles	Investigated in models of muscle-wasting conditions, injury rehabilitation, and metabolic substrate availability.

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Core Mechanism and Function

Peptide	Mechanism of Action	Key Biological Function
IGF-1 LR3	Activates the PI3K-Akt/mTOR and MAPK signaling pathways.	Promotes satellite cell activation and protein synthesis while inhibiting protein degradation pathways.

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Clinical Potential

While IGF-1 LR3 is strictly a research compound, its biological profile is a focal point for several therapeutic inquiries:

Skeletal Muscle Therapeutics: Researching the acceleration of muscle fiber repair and the reversal of atrophy.
Metabolic Research: Exploring its insulin-mimetic properties for improving glucose uptake and insulin sensitivity.
Regenerative Science: Studying its role in increasing bone mineral density and upregulating collagen synthesis in tendons and ligaments.
Cardiovascular Health: Investigating potential roles in maintaining cellular homeostasis and improving heart function in post-infarction repair models.

Strictly RUO: This product is for Research Use Only. It is not FDA-approved for human or veterinary use.

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